Measuring the Impact of Dielectro- Phoresis on Cell Physiology Using a High-content Screening Platform
نویسندگان
چکیده
Here we show the design and implementation of a microfabricated platform for screening the effects of electric fields on mammalian cells. Specifically, we have screened for electric field conditions that are commonly used in the manipulation of cells using dielectrophoresis. To assay the physiological state of the cells, we constructed and cloned a stress-reporting cell line. Results obtained with this platform indicate that both high field strengths and low-frequency fields adversely affect cell physiology.
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